Most of the blade work I have experience with requires both hands. (One on the hilt, and the other resting against the pommel for additional control and agility.) So, losing either arm will have a very serious effect on one’s ability to fight effectively.
That said, feel free to look up Götz von Berlichingen. He was a German mercenary who lost his dominant hand in 1504, and continued fighting for decades using an iron prosthetic. (Just don’t ask me to type another umlaut for awhile, Firefox goes nuts whenever I try the alt+ code.)